In vitro Antimalarial Activity of 11 Terpenes Isolated from Ocimum gratissimum and Cassia alata Leaves. Screening of Their Binding Affinity with Haemin
Auteur(s): Kayembe Sungula JeanNom de la revue/Journal: Journal of Plant Studies
Mois: février
Volume: 1
Numéro: 2
Année: 2012
pages: 168-172
Résumé
<p>Abstract<br>Eleven terpenes extracted from Cassia alata and Ocimum gratissimum leaves were screened for in vitro<br>antimalarial activity against Plasmodium falciparum and for their binding affinity with haemin in ethylene<br>Glycol-water 3:7 solvent. Nine terpenes have promising antimalarial activity with IC50 values below 1μg/ml; two<br>terpenes showed a good activity with IC50 values below 4μg/ml. All the terpenes bind strongly with haemin as<br>shown by variation of absorbance of the haemin at λ 600nm in UV-Visible spectrum.<br> </p>