In vitro anti-malarial activity of 20 quinones isolated from four plants used by traditional healers in the Democratic Republic of Congo
Auteur(s): Kayembe Sungula JeanNom de la revue/Journal: Journal of Medicinal Plants Research
Mois: juin
Volume: 4
Numéro: 11
Année: 2010
pages: 991-994,
Résumé
<p>The anti-malarial activity of 20 quinones isolated from Cassia alata, Cassia occidentalis, Garcinia kola<br>and Ocimum basilicum was investigated in vitro using the micro dilution test of Desjardin by a visual<br>evaluation on thin blood smears. The six quinones isolated from C. occidentalis, three from C. alata and<br>three from O. basilicum were found to be the most active with an IC50 value of below 1 μg/ml. The others<br>quinones showed a moderate activity with IC50 values of between 5 and 20 μg/ml.</p>