Anti-inflammatory and antioxidant activities of Rungia congoensis, a traditional vegetable consumed by Yombe people from Kongo Central area (DR. Congo)
Auteur(s): Mutwale Kapepula Paulin, Kasongo Kawayidiko Michel, Duki Mpanzu Arthur, Ngombe Kabamba Nadège, Masiala Tsobo ChristopheNom de la revue/Journal: Natural product research
Mois: janvier
Volume: 33
Numéro: 11
Année: 2019
pages: 1650-1654
Résumé
<p><i>Rungia congoensis</i><span style="background-color:rgb(255,255,255);color:rgb(33,33,33);">, a traditional vegetable from Kongo Central area (DR. Congo) was studied for establishing microscopic characters and characterised by chromatographic techniques and their </span><i>in vitro</i><span style="background-color:rgb(255,255,255);color:rgb(33,33,33);"> biochemical activities against ROS production were evaluated in cellular models and on an enzyme, myeloperoxidase (MPO), involved in inflammation. Microscopically leaf can be characterised by non-glandular and glandular trichomes, sinuous anticlinal epidermal cells, diacytic stomata and helical vessels. Methanolic extract displayed high cellular antioxidant activity at the concentrations range of 0.1-10 μg mL</span>-1<span style="background-color:rgb(255,255,255);color:rgb(33,33,33);"> and 1-20 μg mL</span>-1<span style="background-color:rgb(255,255,255);color:rgb(33,33,33);"> using lucigenin on neutrophils and DCFH-DA on HL 60, respectively. This extract also showed, more efficient effects on extracellular and intracellular ROS production and MPO activity. Antioxidant and anti-inflammatory activities of </span><i>R. congoensis</i><span style="background-color:rgb(255,255,255);color:rgb(33,33,33);"> were significantly higher, positively correlated with their phytochemical constituents such as flavonoids, iridoids and phenolic acids; and could justify their use as traditional vegetable and potent local nutraceutical resource.</span></p>